Women in England will be allowed to take an early abortion pill at home, under a government plan due to take effect by the end of the year.
Currently, women ending a pregnancy in its first 10 weeks have to take two pills at a clinic 24 to 48 hours apart,
This avoids the risk of women miscarrying while on the journey home.
The chief medical officer said the move would increase choice for women, and ensure they received "safe and dignified care".
Professor Dame Sally Davies said: "Abortion can be a difficult experience so it is important that women feel safe and as comfortable as possible."
Legalising the home use of misoprostol was also welcomed by leading gynaecologists.
Professor Lesley Regan, president of the Royal College of Obstetricians and Gynaecologists (RCOG), said it was "a major step forward for women's healthcare".
"This simple and practical measure will provide women with significantly more choice and is the most compassionate care we can give them" she added.
"It will allow women to avoid distress and embarrassment of bleeding and pain during their journey home from an unnecessary second visit to a clinic or hospital."
But the Society for the Protection of Unborn Children said the move "further trivialises abortion".
"The abortion pill puts women through a terrible emotional and physical ordeal.
"The determination of the abortion industry to push women to undergo this in their own home with no real medical supervision illustrates their cavalier attitude when it comes to the well-being of women."
What is a medical abortion?
Official government figures show that each year around 180,000 abortions are carried out in England, with medical abortions the most common way of ending an unwanted pregnancy.
Medical abortion involves taking two types of tablet.
The first, mifepristone, stops the hormone that allows the pregnancy to continue working.
The second, misoprostol, is normally taken 24 to 48 hours later, and encourages the womb to contract to pass the pregnancy.
After four to six hours, the lining of the womb breaks down, causing bleeding and loss of the pregnancy.
The Department of Health said the change would come into force by the end of 2018.
It says it will now work closely with doctors to develop clinical guidance for all professionals to follow when providing the abortion pill to patients.
Four in five terminations are early medical abortions, carried out before 10 weeks gestation, so the majority of women seeking abortions will now have the option for home-use.
Women wanting an early abortion will be given the usual checks under the Abortion Act.
They will be free to choose to take the second abortion pill in a clinic if they wish.