Russian opposition figure Alexei Navalny is unconscious in hospital with suspected poisoning, his spokeswoman has said.
The anti-corruption campaigner fell ill during a flight and the plane made an emergency landing in Omsk, Kira Yarmysh said, adding that they suspected something had been mixed into his tea.
A hospital source confirmed Mr Navalny was in a serious condition.
Mr Navalny, 44, is a staunch critic of President Vladimir Putin.
In June he described a vote on constitutional reforms as a "coup" and a "violation of the constitution". The reforms allow Mr Putin to serve another two terms in office.
What did the spokeswoman say?
Kira Yarmysh, the press secretary for the Anti-Corruption Foundation, which Mr Navalny founded in 2011, tweeted: "This morning Navalny was returning to Moscow from Tomsk.
"During the flight, he felt ill. The plane made an urgent landing in Omsk. Alexei has toxic poisoning. Right now we are going to hospital."
She added: "We suspect that Alexei was poisoned by something mixed into [his] tea. It was the only thing he drank since morning.
"Doctors are saying that the toxic agent absorbed faster through the hot liquid. Right now Alexei is unconscious."
Ms Yarmysh later tweeted that Mr Navalny was in intensive care, on a ventilator and in a coma.
She said doctors were initially ready to share any information but were now saying the toxicology tests were delayed and were "clearly playing for time, and not saying what they know".
The intensive care unit was now full of police officers, she said.
The Tass news agency quoted one source at the Omsk Emergency Hospital as saying: "Alexei Anatolyevich Navalny, born in 1976. Poisoning intensive care."
Images on social media showed Mr Navalny being taken on a stretcher to an ambulance on the airport runway.
Who is Alexei Navalny?
He made a name for himself by exposing official corruption, labelling Mr Putin's United Russia as "the party of crooks and thieves", and has served several jail terms.
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In 2011 he was arrested and imprisoned for 15 days following protests over vote-rigging by Mr Putin's United Russia party in parliamentary elections.
Mr Navalny was briefly jailed in July 2013 on embezzlement charges but denounced the sentence as political.
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